Evidence

The Science Library

The peer-reviewed research behind every protocol in Beyond The Scale. Start with the anchor studies, then go as deep as you want.

Anchor studies

A curated set of the landmark studies behind the book's core claims, in plain language.

The medication does what it promises

Weekly semaglutide produced about 15 percent average body weight loss over 68 weeks.

The trial that moved obesity medicine from single digits to double digits, and the reason the modern GLP-1 era exists.

RCTHuman

Weekly tirzepatide produced up to about 21 percent average body weight loss over 72 weeks.

The dual-hormone agent that raised the ceiling again and set the benchmark the next generation is measured against.

RCTHuman

In people with obesity and established heart disease but without diabetes, semaglutide reduced major cardiovascular events by about 20 percent.

Evidence that the benefit reaches past the scale, and the clearest case that these drugs are more than cosmetic.

RCTHuman

What the scale does not show

A meaningful share of the weight lost during therapy is lean mass rather than fat when protein and resistance training are inadequate.

Why the scale alone hides the cost, and why body composition is the number that actually matters.

Systematic ReviewHuman

Real-world users of GLP-1 medications show a measurable rise in micronutrient deficiencies.

Eating less does not only mean fewer calories. It means fewer of the vitamins and minerals your body runs on.

CohortHuman

What actually protects you

Adding resistance training during GLP-1 weight loss preserved lean body mass that was otherwise lost.

The most actionable finding in the book. The muscle is protectable, but only if you do the work.

Clinical TrialHuman

Adequate protein meaningfully increases the muscle and strength gained from resistance training.

The dosing logic behind protecting lean mass, anchored to the tissue you are trying to keep.

Meta-analysisHuman

What happens if you stop

After stopping semaglutide, participants regained about two-thirds of the weight they had lost within a year.

The exit is not neutral. Stopping without a plan tends to undo the result.

RCT extensionHuman

Modeling of the regain curve shows weight returns along a predictable nonlinear path after discontinuation.

Regain is not random. It follows a shape, which means it can be anticipated and planned for.

Meta-regressionHuman

The experience itself

Food noise, the intrusive and persistent preoccupation with food, was formally defined and measured.

Putting a name and a metric to the experience patients describe, and to what these drugs quiet.

ConsensusHuman

The complete reference list

The full peer-reviewed reference list behind Beyond The Scale, spanning endocrinology, body composition, mitochondrial function, methylation, and more.

Download the full reference list (PDF)